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CapSys Capsule filling system
Purpose
of this tool is to aid formulation development of powders for hard capsules.
API: true density
mg/mm
3
API: bulk density
mg/mm
3
API: mass*
mg
API: shape
spherical, smooth surface
spherical, rough
platelet
needle
API: d50
micrometer
API: ffc
Excipient
Formulation F1
F2
F3
F4
F5
Excipient blend: true density
mg/mm
3
Excipient blend: bulk density
mg/mm
3
Powder densification in encapsulator resulting in solid fraction of
Overall mass
mg
blend
true density
mg/mm
3
bulk density
mg/mm
3
1
1.21
0.47
2
1.21
0.51
3
1.64
0.61
4
1.55
0.64
5
1.24
0.64
* final salt form; not free base
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